期刊
NEUROIMAGE
卷 85, 期 -, 页码 6-27出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.05.004
关键词
Review; Near-infrared spectroscopy (NIRS); Near-infrared imaging (NIRI); Functional near-infrared spectroscopy (fNIRS); Functional near-infrared imaging (fNIRI); Continuous wave; Brain activity; Instrumentation
资金
- Swiss National Science Foundation
- Nano-Tera
- CHIRP1 ETH Research Grant [CHI-02 09-3]
- Clinical Research Priority Programs Tumor Oxygenation and Molecular Imaging
This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy- and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. (C) 2013 Elsevier Inc. All rights reserved.
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