期刊
NEUROIMAGE
卷 88, 期 -, 页码 32-40出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.10.066
关键词
Motor skill learning; Diffusion tensor imaging; Fractional anisotropy; White matter plasticity
资金
- NICHHD [1R21HD053608-01A1, 1T32HD057845-01A2, 1R01HD072080-01]
- NIDRR grant [H133E120010]
- NCCAM grant [1F32AT007800-01]
- Neilsen Foundation, Brinson Foundation,
- FP7-PEOPLE-2012-CIG-334201 (REMAKE)
- Center for Translational Imaging, Department of Radiology, Northwestern University
The purpose of this study is to identify white matter microstructure changes following bilateral upper extremity motor skill training to increase our understanding of learning-induced structural plasticity and enhance clinical strategies in physical rehabilitation. Eleven healthy subjects performed two visuo-spatial motor training tasks over 9 sessions (2-3 sessions per week). Subjects controlled a cursor with bilateral simultaneous movements of the shoulders and upper arms using a body machine interface. Before the start and within 2 days of the completion of training, whole brain diffusion tensor MR imaging data were acquired. Motor training increased fractional anisotropy (FA) values in the posterior and anterior limbs of the internal capsule, the corona radiata, and the body of the corpus callosum by 4.19% on average indicating white matter microstructure changes induced by activity-dependent modulation of axon number, axon diameter, or myelin thickness. These changes may underlie the functional reorganization associated with motor skill learning. (C) 2013 Elsevier Inc. All rights reserved.
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