期刊
NEUROIMAGE
卷 89, 期 -, 页码 181-191出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.12.014
关键词
Best frequency; Cortical distance; Optical imaging; Primary auditory cortex; Tonotopy
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23115516, 25115725]
- JSPS [25290006, 25670719]
- Grants-in-Aid for Scientific Research [25670719, 25115725] Funding Source: KAKEN
Although orderly representation of sound frequency over space is a hallmark feature of the primary auditory cortex (A1), the quantitative relationship between sound frequency and cortical position is unclear. We examined this relationship in the guinea pig A1 by presenting a series of stimulus tones with a wide frequency range, and recording the evoked cortical responses using an optical imaging technique with high spatial resolution. We identified the cortical positions of three best-frequency indices for each tone: the onset response position, the peak amplitude position, and the maximum rise rate position of the response. We found a nonlinear log frequency-position relationship for each of the three indices, and the frequency-position relationship was always well described by a Greenwood equation, with correlation coefficients greater than 0.98. The cortical magnification factor, measured in octave/mm, was found to be a function of frequency, i.e. not a constant. Our results are novel in that they demonstrate a quantitative relationship between sound frequency and cortical position in the guinea pig A1, as described by the Greenwood equation. (c) 2013 Elsevier Inc. All rights reserved.
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