期刊
NEUROIMAGE
卷 83, 期 -, 页码 817-825出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.05.115
关键词
Real-time fMRI; Dopamine; Substantia nigra; Neurofeedback; Skin conductance response
资金
- ETH Postdoctoral Fellowship
- Swiss National Science Foundation Project [CR3213_138260]
- KFSP on Neuro-Rehabilitation of the University of Zurich
- Deutsche Forschungsgemeinschaft (DFG)
- National Center of Competence in Research on Neural Plasticity and Repair of the Swiss National Science Foundation
The dopaminergic system is involved in reward encoding and reinforcement learning. Dopaminergic neurons from this system in the substantia nigra/ventral tegmental area complex (SN/VTA) fire in response to unexpected reinforcing cues. The goal of this study was to investigate whether individuals can gain voluntary control of SN/VTA activity, thereby potentially enhancing dopamine release to target brain regions. Neurofeedback and mental imagery were used to self-regulate the SN/VTA. Real-time functional magnetic resonance imaging (rtfMRI) provided abstract visual feedback of the SN/VTA activity while the subject imagined rewarding scenes. Skin conductance response (SCR) was recorded as a measure of emotional arousal. To examine the effect of neurofeedback, subjects were assigned to either receiving feedback directly proportional (n = 15, veridical feedback) or inversely proportional (n = 17, inverted feedback) to SN/VTA activity. Both groups of subjects were able to up-regulate SN/VTA activity initially without feedback. Veridical feedback improved the ability to up-regulate SN/VTA compared to baseline while inverted feedback did not. Additional dopaminergic regions were activated in both groups. The ability to self-regulate SN/VTA was differentially correlated with SCR depending on the group, suggesting an association between emotional arousal and neurofeedback performance. These findings indicate that SN/VTA can be voluntarily activated by imagery and voluntary activation is further enhanced by neurofeedback. The findings may lead the way towards a non-invasive strategy for endogenous control of dopamine. (C) 2013 Elsevier Inc. All rights reserved.
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