期刊
NEUROIMAGE
卷 65, 期 -, 页码 488-498出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.10.002
关键词
Visual streams; Prefrontal cortex; Short-term memory; Functional magnetic resonance imaging; Diffusion tractography; Functional connectivity
资金
- National Institutes of Health [R01NS44825]
- Human Frontiers Science Program
- Uehara Memorial Foundation (Japan)
- Eunice Shriver Kennedy National Institute of Child Health and Development [R21HD069001]
- Biomedical Technology Program of the National Center for Research Resources (NCRR), National Institutes of Health
Visual information is largely processed through two pathways in the primate brain: an object pathway from the primary visual cortex to the temporal cortex (ventral stream) and a spatial pathway to the parietal cortex (dorsal stream). Whether and to what extent dissociation exists in the human prefrontal cortex (PFC) has long been debated. We examined anatomical connections from functionally defined areas in the temporal and parietal cortices to the PFC, using noninvasive functional and diffusion-weighted magnetic resonance imaging. The right inferior frontal gyrus (IFG) received converging input from both streams, while the right superior frontal gyrus received input only from the dorsal stream. Interstream functional connectivity to the IFG was dynamically recruited only when both object and spatial information were processed. These results suggest that the human PFC receives dissociated and converging visual pathways, and that the right IFG region serves as an integrator of the two types of information. (C) 2012 Elsevier Inc. All rights reserved.
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