4.7 Article

Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment

期刊

NEUROIMAGE
卷 59, 期 2, 页码 957-967

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.08.062

关键词

Neuroimaging; In vivo diffusion kurtosis Imaging; Transgenic rat model; Huntington disease; Neurodevelopment

资金

  1. EC [LSHB CT 2005 512146, LSHC CT 2004 503569]
  2. Interuniversity Attraction Poles (IUAP) NIMI [P6/38]
  3. Hereditary Disease Foundation
  4. IWT (Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen))

向作者/读者索取更多资源

Huntington Disease (HD) is a fatal neurodegenerative disorder, caused by a mutation in the Huntington gene. Although HD is most often diagnosed in mid-life, the key to its clinical expression may be found during brain maturation. In the present work, we performed in vivo diffusion kurtosis imaging (DKI) in order to study brain microstructure alterations in developing transgenic HD rat pups. Several developing brain regions, relevant for HD pathology (caudate putamen, cortex, corpus callosum, external capsule and anterior commissure anterior), were examined at postnatal days 15 (P15) and 30 (P30), and DKI results were validated with histology. At P15, we observed higher mean (MD) and radial (RD) diffusivity values in the cortex of transgenic HD rat pups. In addition, at the age of P30, lower axial kurtosis (AK) values in the caudate putamen of transgenic HD pups were found. At the level of the external capsule, higher MD values at P15 but lower MD and AD values at P30 were detected. The observed DKI results have been confirmed by myelin basic protein immunohistochemistry, which revealed a reduced fiber staining as well as less ordered fibers in transgenic HD rat pups. These results indicate that neuronal development in young transgenic HD rat pups occurs differently compared to controls and that the presence of mutant huntingtin has an influence on postnatal brain development. In this context, various diffusivity parameters estimated by the DKI model are a powerful tool to assess changes in tissue microstructure and detect developmental changes in young transgenic HD rat pups. (C) 2011 Elsevier Inc. All rights reserved.

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