期刊
NEUROIMAGE
卷 62, 期 2, 页码 720-725出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.01.049
关键词
EPI; Partial Fourier; Zoomed-EPI; Inner volume; Multiplexed EPI; Multiband; Simultaneous; SIR; SER; Twice-refocused SE diffusion; Bipolar gradient; Layer specific; Resting state; Columnar level; BOLD; Functional imaging; fMRI
资金
- National Institutes of Health [R01 EB000331, P41 RR08079, RO1 EB002009, 1R44NS073417, 5R44NS063537]
MRI pulse sequences designed to increase the speed and spatial resolution of fMRI have always been a hot topic. Here, we review and chronicle the history behind some of the pulse sequence ideas that have contributed not only to the enhancement of fMRI acquisition but also to diffusion imaging. (i) Partial Fourier EPI allows lengthening echo trains for higher spatial resolution while maintaining optimal TE and BOLD sensitivity. (ii) Inner-volume EPI renamed zoomed-EPI, achieves extremely high spatial resolution and has been applied to fMRI at 7 Tesla to resolve cortical layer activity and columnar level fMRI. (iii) An early non-BOLD approach while unsuccessful for fMRI created a diffusion sequence of bipolar pulses called 'twice refocused spin echo' now widely used for high-resolution DTI and HARDI neuronal fiber track imaging. (iv) Multiplexed EPI shortens TR to a few hundred milliseconds, increasing sampling rates and statistical power in fMRI. (C) 2012 Elsevier Inc. All rights reserved.
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