期刊
NEUROIMAGE
卷 62, 期 2, 页码 665-671出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.10.057
关键词
Functional MRI; Multi-echo acquisition; BOLD contrast; Quantification; Z-shimming
资金
- European Union [PL 950870]
- NIH [1R01 EB002618-01, 1R41NS062474-01]
- DoE/The MIND Research Network [DE-FG02-99ER62764]
The rapid development of fMRI was paralleled early on by the adaptation of MR spectroscopic imaging (MRSI) methods to quantify water relaxation changes during brain activation. This review describes the evolution of multi-echo acquisition from high-speed MRSI to multi-echo EPI and beyond. It highlights milestones in the development of multi-echo acquisition methods, such as the discovery of considerable gains in fMRI sensitivity when combining echo images, advances in quantification of the BOLD effect using analytical biophysical modeling and interleaved multi-region shimming. The review conveys the insight gained from combining fMRI and MRSI methods and concludes with recent trends in ultra-fast fMRI, which will significantly increase temporal resolution of multi-echo acquisition. (C) 2011 Elsevier Inc. All rights reserved.
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