期刊
NEUROIMAGE
卷 57, 期 4, 页码 1480-1491出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.04.030
关键词
Aging; LOU/c rat; Biophysical models; Intrinsic optical imaging; Bayesian statistical methods
资金
- Fonds de la Recherche en Sante du Quebec
- RQRV
- Vanier Canada Graduate Scholarship
- NSERC
Neuronal, vascular and metabolic factors result in a deterioration of the cerebral hemodynamic response with age. The interpretation of neuroimaging studies in the context of aging is rendered difficult due to the challenge in untangling the composite effect of these modifications. In this work we integrate multimodal optical imaging in biophysical models to investigate vascular and metabolic changes occurring in aging. Multispectral intrinsic optical imaging of an animal model of healthy aging, the LOU/c rat, is used in combination with somatosensory stimulation to study the modifications of the hemodynamic response with increasing age. Results are fitted with three macroscopic biophysical models to extract parameters, providing a phenomenological description of vascular and metabolic changes. Our results show that 1) biophysical parameters are estimable from multimodal data and 2) parameter estimates in this population change with aging. (C) 2011 Elsevier Inc. All rights reserved.
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