期刊
NEUROIMAGE
卷 54, 期 4, 页码 2659-2671出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2010.10.050
关键词
Aging; Cerebrovascular health; Cerebrovascular risk; Cortical thickness; Brain structure
资金
- National Institute of Neurologic Disorders and Stroke [K23NS062148, K23NS06214802S1, R01NS052585]
- National Institute of Nursing Research [R01NR010827]
- National Institute on Aging [P60AG08812, P01AG004390, K01AG24898, AG02238]
- Medical Research Service VA
- National Institutes of Health through the Roadmap for Medical Research [P41-RR14075, BIRN002, U24 RR021382, R01EB006758, U54 EB005149]
We examined how wide ranges in levels of risk factors for cerebrovascular disease are associated with thickness of the human cerebral cortex in 115 individuals ages 43-83 with no cerebrovascular or neurologic history. Cerebrovascular risk factors included blood pressure, cholesterol, body mass index, creatinine, and diabetes-related factors. Variables were submitted into a principal components analysis that confirmed four orthogonal factors (blood pressure, cholesterol, cholesterol/metabolic and glucose). T1-weighted MRI was used to create models of the cortex for calculation of regional cortical thickness. Increasing blood pressure factor scores were associated with numerous regions of reduced thickness. Increasing glucose scores were modestly associated with areas of regionally decreased thickness. Increasing cholesterol scores, in contrast, were associated with thicker cortex across the whole brain. All findings were primarily independent of age. These results provide evidence that normal and moderately abnormal levels of parameters used to assess cerebrovascular health may impact brain structure, even in the absence of cerebrovascular disease. Our data have important implications for the clinical management of vascular health, as well as for what is currently conceptualized as normal aging as they suggest that subclinical levels of risk may impact cortical gray matter before a disease process is evident. (C) 2010 Elsevier Inc. All rights reserved.
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