期刊
NEUROIMAGE
卷 53, 期 2, 页码 392-398出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2010.07.017
关键词
GABA; BOLD; fMRI; CBF; CBV; Oxygen metabolism
资金
- The Dunhill Medical Trust
- National Institute of Health Research (NIHR) Oxford Biomedical Research Centre
Coordination between glutamatergic excitatory neurons and gamma-aminobutyric acid (GABA)-ergic inhibitory interneurons is fundamental to the regulation of neuronal firing rates and is believed to have relevance to functional magnetic resonance imaging (fMRI) contrast While much is known regarding the molecular behavior of excitatory and inhibitory processes, comparatively less is known regarding the role of such processes in explaining variations in fMRI and related hemodynamic imaging metrics. The relationship between baseline GABA levels, as measured by MR spectroscopy, and hemodynamic contrasts from four sequences in human visual cortex are investigated (n = 12, field strength = 3 0 T) blood oxygenation level-dependent (BOLD), cerebral blood flow (CBF)-weighted arterial spin labelling (ASL), cerebral blood volume (CBV)-weighted vascular-space-occupancy (VASO), and arterial CBV (aCBV)-weighted inflow VASO (iVASO). Results indicate that baseline GABA levels (GABA+ macromolecules normalized to creatine) inversely correlate with BOLD reactivity (R = -0 70, P = 0 01) and magnitude CBV-weighted VASO reactivity (R = -0 71, P = 0 01) A trend for significance was found between baseline aCBV-weighted iVASO (R = 050, P = 0.10) and baseline GABA A positive correlation was found between baseline CBF-weighted ASL signal and GABA (R = 0.65, P = 0 02) and ASL time-to-peak and baseline GABA (R = 058, P = 0.05). These findings demonstrate that both the dominant BOLD fMRI contrast, as well as other emerging MR hemodynamic contrasts, have signal variations that are linked to baseline GABA levels (C) 2010 Elsevier Inc. All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据