期刊
NEUROIMAGE
卷 51, 期 2, 页码 723-733出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2010.02.056
关键词
CMRO2 bioscale; Quantitative MR imaging; 17-Oxygen imaging; 23-Sodium imaging; Human brain; 9.4 T
The reduction of molecular oxygen to water is the final step of oxidative phosphorylation that couples adenosine triphosphate production to the reoxidation of reducing equivalents formed during the oxidation of glucose to carbon dioxide. This coupling makes the cerebral metabolic rate of oxygen consumption (CMRO2) an excellent reflection of the metabolic health of the brain. A multi-nuclear magnetic resonance (MR) imaging based method for CMRO2 mapping is proposed. Oxygen consumption is determined by applying a new three-phase metabolic model for water generation and clearance to the changing 17-oxygen (O-17) labeled water MR signal measured using quantitative O-17 MR imaging during inhalation of O-17-enriched oxygen gas. These CMRO2 data are corrected for the regional brain tissue mass computed from quantitative 23-sodium MR imaging of endogenous tissue sodium ions to derive quantitative results of oxygen consumption in micromoles O-2/g tissue/minute that agree with literature results reported from positron emission tomography. The proposed technique is demonstrated in the human brain using a 9.4 T MR scanner optimized for human brain imaging. Published by Elsevier Inc.
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