期刊
NEUROIMAGE
卷 49, 期 3, 页码 2141-2157出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.10.086
关键词
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资金
- National Institutes of Health [U54 RR021813]
- National Institute On Aging [AG021431, AG05133, AG016570]
- National Library of Medicine
- National Institute for Biomedical Imaging and Bioengineering
- National Center for Research Resources [LM05639, E1301651, RR019771, A1035041, DA025986]
Here we developed a new method, called multivariate tensor-based surface morphometry (TBM), and applied it to study lateral ventricular Surface differences associated with HIV/AIDS Using concepts from differential geometry and the theory of differential for ins, we created mathematical structures known as holomorphic one-forms, to obtain an efficient and accurate conformal parameterization of the lateral ventricular surfaces in the brain. The new meshing approach also provides a natural way to register anatomical Surfaces across Subjects. and improves on prior methods as it handles surfaces that branch and join at complex 3D Junctions To analyze anatomical differences, we computed new statistics from the Riemannian surface metrics-these retain multivariate information oil local surface geometry We applied this framework to analyze lateral ventricular surface morphometry in 31) MRI data from 11 Subjects with HIV/AIDS and 8 healthy controls Our method detected a 3D profile of surface abnormalities even in this small sample. multivariate statistics on the local tensors gave better effect sizes for detecting group differences, relative to other TBM-based methods including analysis of the Jacobian determinant, the largest and smallest eigenvalues of the Surface metric, and the pair of eigenvalues of the Jacobian matrix The resulting analysis pipeline may improve the power of surface-based morphometry studies of the brain. (C) 2009 Elsevier Inc All rights reserved
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