期刊
NEUROIMAGE
卷 50, 期 3, 页码 1188-1193出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.12.083
关键词
Amygdala; Hippocampus; Novelty; Contextual novelty; Categorical novelty; fMRI
资金
- National Institute of Mental Health [K01-MH083052, R01-MH074567]
- National Center for Research Resources [1-UL1-RR024975]
- Vanderbilt Institute of Imaging Science
Previous research indicates that the amygdala and hippocampus are sensitive to novelty; however, two types of novelty can be distinguished - stimuli that are ordinary, but novel in the current context, and stimuli that are unusual. Using functional magnetic resonance imaging, we examined blood oxygen dependent level (BOLD) response of the human amygdala and hippocampus to novel, commonly seen objects versus novel unusual objects. When presented with the novel common stimuli, the BOLD signal increased significantly in both the amygdala and hippocampus. However, for the novel unusual stimuli, only the amygdala showed an increased response compared to the novel common stimuli. These findings suggest that the amygdala is distinctly responsive to novel unusual stimuli, making a unique contribution to the novelty detection circuit. (C) 2009 Elsevier Inc. All rights reserved.
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