期刊
NEUROIMAGE
卷 47, 期 1, 页码 8-17出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.04.033
关键词
Morphometry; MRI; Alzheimer's disease
资金
- National Center for Research Resources [P41-RR14075, BIRN002, U24 RR021382]
- National Institute for Biomedical Imaging and Bioengineering [R01 EB001550, R01EB006758]
- National Institute for Neurological Disorders and Stroke [R01 NS052585-01]
- Mental illness and Neuroscience Discovery (MIND) Institute
- National Alliance for Medical Image Computing (NAMIC) [U54 EB005149]
- Ellison Medical Foundation
Entorhinal cortex (EC) is a medial temporal lobe area critical to memory formation and spatial navigation that is among the earliest parts of the brain affected by Alzheimer's disease (AD). Accurate localization of EC would thus greatly facilitate early detection and diagnosis of AD. In this study, we used ultra-high resolution ex vivo MRI to directly visualize the architectonic features that define EC rostrocaudally and mediolaterally, then applied surface-based registration techniques to quantify the variability of EC with respect to cortical geometry, and made predictions of its location on in vivo scans. The results indicate that EC can be localized quite accurately based on cortical folding patterns, within 3 mm in vivo, a significant step forward in our ability to detect the earliest effects of AD when clinical intervention is most likely to be effective. (C) 2009 Elsevier Inc. All rights reserved.
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