期刊
NEUROIMAGE
卷 42, 期 2, 页码 1032-1044出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2008.03.057
关键词
cognitive processing speed; diffusion tensor imaging; individual differences; magnetic resonance imaging; neural pathways; neuropsychology
资金
- National Institutes of Health [MH61426, 1 F32 NS43961]
- Department of Veterans Affairs Division of Medicine and Surgery
- National Institute for Neurological Disorders and Stroke [P01 NS 17778, P01 NS40813]
- National Institute of Deafness and communication Disorders [NIH/NIDCD 2 RO1 DC00216]
We investigated the relation between cognitive processing speed and structural properties of white matter pathways via convergent imaging studies in healthy and brain-injured groups. Voxel-based morphometry (VBM) was applied to diffusion tensor imaging data from thirty-nine young health) subjects in order to investigate the relation between processing speed, as assessed with the Digit-Symbol subtest from WAIS-III, and fractional anisotropy, an index of microstructural organization of white matter. Digit-Symbol performance was positively correlated with fractional anisotropy of white matter in the parietal and temporal lobes bilaterally and in the left middle frontal gyrus. Fiber tractography indicated that these regions are consistent with the trajectories of the superior and interior longitudinal fasciculi. In a second investigation, we assessed the effect of white matter damage on processing speed using voxel-based lesion-symptom mapping (VLSM) analysis of data from seventy-two patients with left-hemisphere strokes. Lesions in left parietal white matter, together with cortical lesions in supramarginal and angular gyri were associated with impaired performance. These findings suggest that cognitive processing speed, as assessed by the Digit-Symbol test, is closely related to the structural integrity of white matter tracts associated with parietal and temporal cortices and left middle frontal gyrus. Further, fiber tractography applied to VBM results and the patient finding's suggest that file superior longitudinal fasciculus, a major tract subserving frontoparietal integration, makes a prominent contribution to processing speed. (C) 2008 Elsevier Inc. All rights reserved.
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