期刊
NEUROIMAGE
卷 39, 期 1, 页码 223-230出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2007.08.029
关键词
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资金
- NCRR NIH HHS [S10 RR021179, S10 RR021179-010005] Funding Source: Medline
- NIDCD NIH HHS [R21 DC006892-01, DC006892, R21 DC006892, R21 DC006892-02] Funding Source: Medline
- NINDS NIH HHS [R01 NS038461-03, R01 NS038461-01, R01 NS038461-02, R01 NS038461, R01 NS038461-04, NS038461] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR021179] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038461] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R21DC006892] Funding Source: NIH RePORTER
Manganese-enhanced MRI (MEMRI) has been developed to image brain activity in small animals, including normal and genetically modified mice. Here, we report the use of a MEMRI-based statistical parametric mapping method to analyze sound-evoked activity in the mouse auditory midbrain, the inferior colliculus (IC). Acoustic stimuli with defined frequency and amplitude components were shown to activate and enhance neuronal ensembles in the IC. These IC activity patterns were analyzed quantitatively using voxel-based statistical comparisons between groups of mice with or without sound stimulation. Repetitive 40-kHz pure tone stimulation significantly enhanced ventral IC regions, which was confirmed in the statistical maps showing active regions whose volumes increased in direct proportion to the amplitude of the sound stimuli (65 dB, 77 dB, and 89 dB peak sound pressure level). The peak values of the activity-dependent MEMRI signal enhancement also increased from 7% to 20% for the sound amplitudes employed. These results demonstrate that MEMRI statistical mapping can be used to analyze both the 3D spatial patterns and the magnitude of activity evoked by sound stimuli carrying different energy. This represents a significant advance in the development of MEMRI for quantitative and unbiased analysis of brain function in the deep brain nuclei of mice. (C) 2007 Published by Elsevier Inc.
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