期刊
NEUROIMAGE
卷 42, 期 2, 页码 483-490出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2008.05.026
关键词
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资金
- German Federal Ministry of Education and Research BMBF
- German Research Foundation DFG [618-B4]
Functional magnetic resonance imaging (fMRI) measures neural activity indirectly via its slow vascular/metabolic consequences. At a temporal resolution on the order of seconds, fMRI does not reveal the real 'language of neurons', spelt Out by fast electrical discharges ('spikes') which occur on a time scale of milliseconds. In animal studies, these limitations have been addressed by adding invasive electrode measurements to fMRI Here, we propose to circumvent this inverse problem of fMRI by deriving a noninvasive spike measure from recordings of ultrafast electroencephalography (EEG) signals during fMRI. We demonstrate how in response to median nerve stimulation 600 Hz oscillatory EEG signals can be measured reliably during fMRI. These high-frequency bursts (HFBs) are supposed to reflect Population spikes in the thalamus and the somatosensory cortex, respectively. We show that distinct fMRI activations in these two generator structures can be attributed to spontaneous HFB fluctuations. Thus, our approach allowed the noninvasive identification of neural processes along the thalamocortical pathway unfolding at a millisecond time scale. (C) 2008 Elsevier Inc. All rights reserved.
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