期刊
NEUROIMAGE
卷 42, 期 1, 页码 323-331出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2008.04.176
关键词
somatosensory cortex; vibrotactile stimulation; steady-state oscillation; magnetoencephalography; inter-trial coherence; synthetic aperture magnetometry
We utilized a novel analysis technique to identify brain areas that activate synchronously during the steady-state interval of responses to vibrotactile stimulation of the right index finger. The inter-trial coherence at the stimulation rate (23 Hz) was determined for whole-brain neural activity estimates based on a linearly-constrained minimum variance beamformer applied to the MEG data. Neural activity coherent with the stimulus occurred in the contralateral primary somatosensory cortex in all subjects, and matched well with equivalent dipole modeling of the same data. Subsets of subjects exhibited additional loci of strongly coherent activity in the contralateral primary motor cortex, posterior parictal cortex, and supplementary motor a rea, as well as in deeper brain structures above the brainstem. An activation delay of 7 ins from deep structures to cortical areas was estimated based on the mean phase at each coherent neural source within a single subject. This new approach - volumetric mapping of the statistical parameter of inter-trial coherence in steady-state oscillations - broadens the range of MEG beamformer applications specifically for identifying brain areas that are synchronized to repetitive stimuli. (c) 2008 Elsevier Inc. All rights reserved.
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