期刊
NEUROGENETICS
卷 10, 期 4, 页码 355-358出版社
SPRINGER
DOI: 10.1007/s10048-009-0186-0
关键词
Parkinson's disease; Haplotype; Ashkenazi Jews; LRRK2 G2019S mutation; Founder mutation
资金
- National Parkinson Foundation, Miami, USA
- Tel Aviv Sourasky Medical Center Grant of Excellence
- Wolfson and Kahn Foundations
The LRRK2 G2019S mutation is a major genetic determinant of Parkinson's disease (PD) across the world that occurs at an elevated frequency in Ashkenazi Jews. We determined the LRRK2 haplotypes in 77 G2019S carriers, mostly Ashkenazi Jews, and in 50 noncarrier Ashkenazi PD patients, using 16 genetic markers. A single haplotype was detected in all mutation carriers, indicating that these individuals share a common founder. Using a maximum-likelihood method, we estimate that Ashkenazi Jews with G2019S share a common ancestor who lived similar to 1,830 (95% CI 1,560-2,160) years ago, around the second century, after the second Jewish Diaspora.
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