期刊
NEUROGENETICS
卷 10, 期 3, 页码 173-181出版社
SPRINGER
DOI: 10.1007/s10048-009-0170-8
关键词
Parkinson's disease; Genetic epistasis; Whole-genome association study; Single nucleotide polymorphism; Interaction
资金
- Agencia IDEA
- Consejer a de Innovacion
- Ciencia y Empresa [830882]
- Ciencia [PCT-A41502790-2006, PCT-010000-2006-1]
- Fundacion Alzheimur (Comunidad Autonoma de la Region de Murcia (CARM), Murcia, Spain)
Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson's disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.
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