期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 25, 期 3, 页码 E224-E232出版社
WILEY
DOI: 10.1111/nmo.12075
关键词
diabetes mellitus; gastric emptying; glucose; glycemic control; radiopaque markers; scintigraphy
资金
- European Community [223630]
- Swedish Medical Research Council [13409, 21691, 21692]
- Marianne and Marcus Wallenberg Foundation
- University of Gothenburg
- Centre for Person-Centered Care (GPCC)
- Sahlgrenska Academy
- Faculty of Medicine, University of Gothenburg
- Swedish Nutrition Foundation
- Lund
- Vastra Gotaland Region
- Sahlgrenska University Hospital Foundations
- Diabetes Association in Gothenburg
- Hemocue AB, Angelholm
Background Scintigraphy, the gold standard to measure gastric emptying, is expensive and not widely available. Therefore, we compared emptying of radiopaque markers (ROM) from the stomach, by use of fluoroscopy, with scintigraphy in patients with insulin-treated diabetes. Methods On the same day we measured gastric emptying of 20 ROM using fluoroscopy and scintigraphic emptying of a standard solid meal. The subjects also completed a validated gastrointestinal (GI) symptom questionnaire. Key Results We included 115 patients with insulin-treated diabetes (median age 53, range 21-69 years; 59 women). A moderately strong correlation was demonstrated between scintigraphic (% retained at 2 h) and ROM emptying (markers retained at 6 h) (r = 0.47; P < 0.0001). Eighty-three patients had delayed gastric emptying with scintigraphy, whereas only 29 patients had delayed emptying of ROM. Of the 29 patients with delayed emptying of ROM, 28 also had delayed scintigraphic emptying. The sensitivity and specificity of the ROM test was 34% and 97%, respectively. Significant correlations were only noted between scintigraphic gastric emptying and GI symptom severity, with the strongest correlations for fullness/early satiety (r = 0.34; P < 0.001) and nausea/vomiting (r = 0.30; P < 0.001). Conclusions & Inferences A gastric emptying test with ROM is a widely available screening method to detect delayed gastric emptying in patients with diabetes, where a positive result seems reliable. However, a normal ROM test does not exclude delayed gastric emptying, and if the clinical suspicion of gastroparesis remains, scintigraphy should be performed. Results from scintigraphy also correlate with GI symptom severity, which ROM test did not.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据