期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 21, 期 1, 页码 42-51出版社
WILEY
DOI: 10.1111/j.1365-2982.2008.01194.x
关键词
gastric accommodation; gastric volumes; magnetic resonance imaging; reproducibility; SPECT; stomach
资金
- USPHS NIH [P01 DK068055]
- NIH [C06 RR018898]
- National Center for Research Resources (NCRR) [1 UL1 RR024150-01]
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR018898, UL1RR024150] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK068055, R01DK017238] Funding Source: NIH RePORTER
Our aims were to measure the gastric volume response in excess of ingested meal volume (i.e. gastric accommodation), contribution of swallowed air to this excess, day-to-day variability of gastric volumes measured by MRI and their relationship to volumes measured by single-photon-emission computed tomography (SPECT). In 20 healthy volunteers, fasting and postprandial gastric volumes were measured after technetium(99m)-pertechnetate labeling of the gastric mucosa by SPECT and separately by MRI, using 3D gradient echo and 2D half-Fourier acquisition single-shot turbo spin echo (HASTE) sequences. Ten of these subjects had a second MRI exam to assess intra-individual variation. Thereafter, another 10 subjects had two MRI studies during which they ingested the nutrient in 30 or 150 mL aliquots. During MRI, the postprandial gastric volume change exceeded the ingested meal volume by 106 +/- 12 mL (Mean +/- SEM). The HASTE and gradient echo sequences distinguished air from fluid under fasting and postprandial conditions respectively. This postprandial excess mainly comprised air (61 +/- 5 mL), which was not significantly different when ingested as 30 or 150 mL aliquots. Fasting and postprandial gastric volumes measured by MRI were generally reproducible within subjects. During SPECT, postprandial volumes increased by 158 +/- 18 mL; gastric volumes measured by SPECT were higher than MRI. MRI measures gastric volumes with acceptable performance characteristics; the postprandial excess primarily consists of air, which is not affected by the mode of ingestion. Gastric volumes are technique specific and differ between MRI and SPECT.
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