期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 21, 期 5, 页码 481-491出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2982.2009.01291.x
关键词
enteric nervous system; persistent neuroplasticity; visceral afferent
资金
- NIH [DK62267]
- Crohn's and Colitis Foundation of Canada
- Alberta Heritage Foundation for Medical Research Medical Scientist
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK062267] Funding Source: NIH RePORTER
Inflammation of the gut alters the properties of the intrinsic and extrinsic neurons that innervate it. While the mechanisms of neuroplasticity differ amongst the inflammatory models that have been used, amongst various regions of the gut, and between intrinsic vs extrinsic neurons, a number of consistent features have been observed. For example, intrinsic and extrinsic primary afferent neurons become hyperexcitable in response to inflammation, and interneuronal synaptic transmission is facilitated in the enteric circuitry. These changes contribute to alterations in gut function and sensation in the inflamed bowel as well as functional disorders, and these changes persist for weeks beyond the point at which detectable inflammation has subsided. Thus, gaining a more thorough understanding of the mechanisms responsible for inflammation-induced neuroplasticity, and strategies to reverse these changes are clinically relevant goals. The purpose of this review is to summarize our current knowledge regarding neurophysiological changes that occur during and following intestinal inflammation, and to identify and address gaps in our knowledge regarding the role of enteric neuroplasticity in inflammatory and functional gastrointestinal disorders.
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