期刊
NEUROEPIDEMIOLOGY
卷 42, 期 4, 页码 252-259出版社
KARGER
DOI: 10.1159/000362201
关键词
Dementia; Diabetes; Leisure time physical activity; Obesity; Midlife risk factors; Population cohort
资金
- Swedish Research Council [11267, 2005-8460, 825-2007-7462]
- Swedish Council for Working Life and Social Research [2001-2835, 20012646, 2003-0234, 2004-0150, 2006-0020, 2008-1229, 2004-0145, 2006-0596, 2008-1111, 2010-0870]
- EpiLife [2006-1506]
- WISH [2007-1958]
- Swedish Brain Power
- Alzheimer's Association Zenith Award [ZEN-01-3151]
- Alzheimer's Association Stephanie B. Overstreet Scholars [IIRG-00-2159]
- Bank of Sweden Tercentenary Foundation
- Stiftelsen Soderstrom-Konigska Sjukhemmet
- Stiftelsen for Gamla Tjanarinnor
- Handlanden Hjalmar Svenssons Forskningsfond
- Stiftelsen Professor Bror Gadelius' Minnesfond
Background: There is evidence of a synergistic interaction between obesity and sedentary lifestyle with respect to diabetes. Although diabetes is a known risk factor for dementia, it is unclear if both diseases have common aetiologies. Methods: A community-based sample of 1,448 Swedish women, aged 38-60 years and free of diabetes and dementia in 1968, was followed by means of up to 5 examinations spread over 34 years. 9.6% of all women developed diabetes and 11.4% developed dementia (over 40,000 person-years of follow-up for each disease). Cox proportional hazard regression was used to assess the influence of selected risk factors on both diseases, and the relation between diabetes and dementia. Results: Comparing risk factors for incident diabetes and dementia, both diseases showed a synergistic association with obesity combined with a low level of leisure time physical activity [hazard ratio (HR) for interaction = 2.7, 95% confidence interval (Cl) = 1.2-6.3 for diabetes and HR = 3.3, 95% Cl = 1.1-9.9 for dementia]. Development of diabetes doubled the risk for subsequent dementia (HR = 2.2, 95% Cl = 1.1-4.4), which was slightly reduced upon adjustment for common risk factors. Conclusions: Shared risk factors suggest a similar aetiology for diabetes and dementia and partially explain the association between diseases. (C) 2014 S. Karger AG, Basel
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