期刊
NEUROEPIDEMIOLOGY
卷 43, 期 2, 页码 114-122出版社
KARGER
DOI: 10.1159/000366163
关键词
Aging dementia; Epidemiological methods; Cohort study; Mild cognitive impairment; Prevalence rate; Neuropsychological tests
资金
- Science and Technology Committee, Shanghai, PR China [09DZ1950400]
Background: To establish a prospective cohort to enumerate the prevalence, incidence and risk factors for dementia and mild cognitive impairment (MCI) among residents aged >= 60 in an urban community of Shanghai, China. Methods: Participants received clinical evaluations including physical measurements, demographic and lifestyle questionnaires, physical and neurologic examinations, and neuropsychological testing. Urine and blood samples were collected, aliquoted, and stored. DNA was extracted for Apolipoprotein (APOE) genotyping. Diagnoses of dementia and MCI were made using standard criteria via consensus diagnosis. Results: Among 3,141 participants aged >= 60, 1,438 (45.8%) were men. The average age of participants was 72.3 years (SD 8.1), and they had an average of 11.6 years (SD 4.4) of education. The most common chronic disease of participants was hypertension (56.4%). The frequencies of APOE epsilon 2, epsilon 3 and epsilon 4 were 7.9, 82.7 and 9.4%, respectively. We diag-nosed 156 (5.0%, 95% Cl 4.3-5.8%) participants with dementia. The prevalence rates of Alzheimer's disease and vascular dementia were 3.6% (95% Cl 3.0-4.3%) and 0.8% (95% Cl 0.5-1.1%). Conclusions: The Shanghai Aging Study is the first prospective community-based cohort study of cognitive impairment in China, with a comparable study design, procedures, and diagnostic criteria for dementia and MCI to most previous cohort studies in developed countries. (C) 2014 S. Karger AG, Basel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据