期刊
NEUROEPIDEMIOLOGY
卷 34, 期 2, 页码 99-105出版社
KARGER
DOI: 10.1159/000264828
关键词
Dementia; Alzheimer's disease; Mild cognitive impairment; Hypertension
资金
- NIH [R01 AG017173, R01 AG09029, R01 HG/AG02213]
- Joseph and Florence Mandel Research Fund
- Nickman Family
- GOJO Corp.
- Fullerton Foundation
- Institute for the Study of Aging
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002213] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG017173, R01AG009029] Funding Source: NIH RePORTER
Background: We aimed to determine whether vascular risk factors are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI) in an elderly Arab population. Methods: An Arabic-speaking team performed a door-to-door survey of consecutive residents aged 6 65 years. We estimated the odds of AD or MCI versus normal controls as a function of age, gender, education and presence of vascular factors by multinomial logistic regression with interactions. Results: Out of 767 subjects (54% men), 444 were cognitively normal, 234 had MCI and 89 had AD. AD was significantly associated with hypertension (p = 0.01; OR = 2.08; 95% CI: 1.18-3.65), age (p < 0.0001; OR = 1.19; 95% CI: 1.14-1.24), female gender (p = 0.0016; OR = 3.06; 95% CI: 1.53-6.15) and education (p = 0.0002; OR = 0.75; 95% CI: 0.65-0.88). MCI was significantly associated with hypertension (p = 0.0042; OR = 1.69; 95% CI: 1.25-2.44), age (p < 0.0001; OR = 1.06; 95% CI: 1.03-1.09) and education (p < 0.0001; OR = 0.76; 95% CI: 0.71-0.83), but not with gender. Conclusions: Hypertension, older age and low education significantly increase the probability of AD and MCI. The effect of hypertension on the odds of AD versus controls is over and above the effects of age, gender and education. For MCI versus controls there is no gender effect, and the effect of hypertension is over and above the effects of age and education. Copyright (c) 2009 S. Karger AG, Basel
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