期刊
NEUROEPIDEMIOLOGY
卷 31, 期 2, 页码 115-121出版社
KARGER
DOI: 10.1159/000148257
关键词
autonomic function; cognitive impairment; heart rate variability; cohort studies
资金
- British Medical Research Council
- British Economic and Social Research Council
- British Heart Foundation
- UK Health and Safety Executive
- UK Department of Health
- National Heart Lung and Blood Institute [HL36310]
- US, National Institutes of Health
- National Institute on Aging [AG13196]
- Agency for Health Care Policy Research [HS06516]
- The John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-Economic Status and Health
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G19/35, G0100222, G8802774] Funding Source: researchfish
- AGENCY FOR HEALTHCARE RESEARCH AND QUALITY [R01HS006516] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL036310] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R37AG013196, R01AG013196] Funding Source: NIH RePORTER
Background: To examine the relationship between reduced heart rate variability (HRV) and cognitive function in middleaged adults in the general population. Methods: HRV, in both time and frequency domains, and cognitive functioning were measured twice in 5,375 male and female participants of the UK Whitehall II study (mean ages = 55 and 61 years, respectively). Logistic regression was used to model associations between HRV and cognition [short-term verbal memory, reasoning (Alice Heim 4-I), vocabulary, phonemic and semantic fluency]. Cross-sectional associations were assessed at both waves, and longitudinal associations were measured as changes in cognition over the 5-year follow-up. Results: No consistent associations were found in men or women, either in the cross-sectional, prospective or the longitudinal analyses of declines in cognition. Conclusion: Reduced cardiovascular autonomic function does not contribute to cognitive impairment in this middle-aged population. Further studies are needed to verify the potential role of HRV measures in predicting the degeneration of cognitive function at older ages. Copyright (C) 2008 S. Karger AG, Basel.
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