期刊
NEUROENDOCRINOLOGY
卷 96, 期 2, 页码 103-110出版社
KARGER
DOI: 10.1159/000338400
关键词
17 beta-estradiol; Estrogen receptor alpha; Estrogen receptor beta; GPR30 (GPER1); G alpha q-coupled membrane estrogen receptor; mGluR1 receptor; Gonadotropin-releasing hormone neuron; Proopiomelanocortin neuron
资金
- National Institutes of Health [DA13185, HD04263, DK68098, NS38809]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD042635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068098] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038809, R56NS038809, R01NS039495] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA013185] Funding Source: NIH RePORTER
Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ER alpha and ER beta, and a number of putative membrane ERs, including ER alpha, ER beta, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and physiology has been discovered. In other cases, the identity or the function remains to be elucidated. This mini-review attempts to synthesize our understanding of 17 beta-estradiol membrane signaling within hypothalamic circuits involved in homeostatic functions, focusing on reproduction and energy balance. Copyright (C) 2012 S. Karger AG, Basel
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