期刊
NEURODEGENERATIVE DISEASES
卷 12, 期 4, 页码 212-218出版社
KARGER
DOI: 10.1159/000348595
关键词
Substantia nigra hyperechogenicity; Bionnarker; Neuroinnaging; General community; Parkinson's disease; Diagnostic accuracy
资金
- Medical University of Innsbruck [IFTZ 2007152]
- Tustertaler Verein zur Pravention von Herz- und Hirngefaesserkrankungen
- mayor of Bruneck, and the Assessorat fuer Gesundheit', Province of Bolzano, Italy
Background: The clinical diagnosis of Parkinson's disease (PD) is currently anchored in its cardinal motor symptoms. According to hospital-based studies, an enlarged echogenicity in the area of the substantia nigra (SN) assessed with transcranial sonography (TCS) may represent a useful biomarker in the diagnosis of PD. Objective:To evaluate SN hyperechogenicity as a marker for PD in the Bruneck Study cohort, which is representative of the general elderly community. Methods: The diagnostic accuracy of TCS in distinguishing clinically diagnosed PD from nonparkinsonian subjects was assessed in 574 subjects from this cohort. Results: There was a good diagnostic accuracy of TCS in distinguishing PD subjects from nonparkinsonian subjects with an area under the curve value of 0.82. At a receiveroperating characteristic cut:ye analysis-based cutoff value for SN hyperechogenicity of 0.18 cm2, TCS had a sensitivity of 88.2% (95% confidence interval, Cl, 64.4-98.0), a specificity of 77.0% (95% Cl 72.8-80.6), a positive predictive value of 12.7% (95% Cl 7.8-20.0) and a negative predictive value of 99.4% (95% Cl 97.8-100.0) for subjects with clinically definite PD at baseline. When analyzing the same population after 5 years with regard to the presence of known and newly diagnosed PD cases, baseline TCS yielded very similar diagnostic accuracy values. Conclusion: SN hyperechogenicity may represent a useful bionnarker for PD not only in a hospital-based setting but also in the general community. Copyright (C) 2013 S.Karger AG, Basel
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