期刊
NEURODEGENERATIVE DISEASES
卷 9, 期 3, 页码 107-120出版社
KARGER
DOI: 10.1159/000331327
关键词
Human umbilical cord blood cell transplantation; Amyotrophic lateral sclerosis; Transgenic mouse model
资金
- Deutsche Gesellschaft fur Muskelkranke
- Deutsche Forschungsgemeinschaft [Pe 924/2-2]
Background: Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons in the spinal cord, brain stem and motor cortex and has only marginal therapeutic options. Adult stem cells have recently come into the focus of neurological research. While replacement of motor neurons by stem cells currently appears not feasible, there is evidence that non-neuronal cells can be neuroprotective. Objective: Therefore, we evaluated the effects of direct intraspinal administration of human umbilical cord blood cells in a G93A transgenic mouse model of ALS before (day 40) and after symptom onset (day 90). Methods: Treatment effects were assessed by survival analysis, behavioral tests, histological and biochemical analyses. Results: Treatment at early stages increased survival, led to significant improvements in motor performance and significantly reduced motor neuron loss and astrogliosis in the spinal cord. Interestingly females tended to respond better to treatment than males. Conclusion: This study confirms the neuroprotective potential of human umbilical cord blood cells and encourages further investigations. Copyright (C) 2011 S. Karger AG, Basel
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