期刊
NEUROCHEMISTRY INTERNATIONAL
卷 77, 期 -, 页码 68-77出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2014.06.002
关键词
Cancer; Cancer stem cells; Glioblastoma; Glioma; MicroRNA
资金
- HEAD-RUSH Brain Tumor Research Professorship
- Roger Loff Memorial Fund for GBM Research
- NIH [R21CA161704, R01NS075995, R01CA158800]
MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their dysregulation plays major roles in many cancer types. Gliomas are cancers arising from the central nervous system. The most malignant and common glioma is glioblastoma multiforme (GBM), and even with aggressive treatment (surgical resection, chemotherapy, and radiation), average patient survival remains less than 2 years. In this review we will summarize the current findings regarding microRNAs in GBM and the biological and clinical implications of this data. (C) 2014 Elsevier Ltd. All rights reserved.
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