期刊
NEUROCHEMISTRY INTERNATIONAL
卷 63, 期 7, 页码 660-669出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2012.12.008
关键词
Reactive astrocyte; Gliosis; Status Epilepticus; Review; Epileptogenesis; Inflammation; Epilepsy; Seizure
资金
- Epilepsy Foundation Predoctoral Fellowship [NIH NS066774, NIH NS062419, NIH RC1 NS069033, NIH T32 NS076067]
Status epilepticus (SE) is a life threatening condition that often precedes the development of epilepsy. Traditional treatments for epilepsy have been focused on targeting neuronal mechanisms contributing to hyperexcitability, however, approximately 30% of patients with epilepsy do not respond to existing neurocentric pharmacotherapies. A growing body of evidence has demonstrated that profound changes in the morphology and function of astrocytes accompany SE and persist in epilepsy. Astrocytes are increasingly recognized for their diverse roles in modulating neuronal activity, and understanding the changes in astrocytes following SE could provide important clues about the mechanisms underlying seizure generation and termination. By understanding the contributions of astrocytes to the network changes underlying epileptogenesis and the development of epilepsy, we will gain a greater appreciation of the contributions of astrocytes to dynamic circuit changes, which will enable us to develop more successful therapies to prevent and treat epilepsy. This review summarizes changes in astrocytes following SE in animal models and human temporal lobe epilepsy and addresses the functional consequences of those changes that may provide clues to the process of epileptogenesis. (C) 2012 Elsevier Ltd. All rights reserved.
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