期刊
NEUROCHEMISTRY INTERNATIONAL
卷 62, 期 7, 页码 982-987出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2013.03.012
关键词
Kainate receptors; Modulation; Glutamate; GABA; Ionotropic; Metabotropic; Subunits
资金
- Spanish Ministry of Science and Education [BFU2006-14155]
Kainate receptors (KARs) are members of the glutamate receptor family, which also includes two other ionotropic subtypes, i.e. NMDA- and AMPA-type receptors, and types I, II and III metabotropic glutamate receptors. KARs mediate synaptic transmission postynaptically through their ionotropic capacity, while presynaptically, they modulate the release of both GABA and glutamate through operationally diverse modus operandi. At hippocampal mossy fiber (MF)-CA3 synapses, KARs have a biphasic effect on glutamate release, such that, depending on the extent of their activation, a facilitation or depression of glutamate release can be observed. This modulation is posited to contribute to important roles of KARs in short- and long-term plasticity. Elucidation of the modes of action of KARs in their depression and facilitation of glutamate release is beginning to gather impetus. Here we will focus on the cellular mechanisms involved in the modulation of glutamate release by presynaptic MAR activation at MF-CA3 synapses, a field that has seen significant progress in recent years. (C) 2013 Elsevier Ltd. All rights reserved.
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