期刊
NEUROCHEMISTRY INTERNATIONAL
卷 52, 期 3, 页码 363-367出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2007.07.015
关键词
Alzheimer's disease; presenilin; gonadectomy; 17 beta-estradiol; testosterone; western blotting
Mutations in presenilin (PS) genes cause majority of early onset Alzheimer's disease (AD), an age related neurodegenerative disorder. PS proteins undergo proteolytic cleavage to produce biologically active fragments, which constitute the catalytic core of the gamma-secretase enzyme. This enzyme cleaves beta-amyloid precursor protein (beta APP) to generate A beta peptides, which are influenced by sex steroids. Recently we have reported the downregulation of PSI expression by sex steroids in the brain of adult mice. Here we have examined the effect of gonadectomy and subsequent administration of gonadal hormones 17 beta-estradiol and testosterone on the level of PS2 C-terminal fragment (CTF) in the cerebral cortex of adult and old AKR strain mice of both sexes. PS2 expression was downregulated following gonadectomy, but upregulated by supplementation of gonadal steroids in both age groups and sexes. Thus these results demonstrate up-regulation of PS2 protein expression by sex steroids, which in turn may influence PS2 associated brain functions. (C) 2007 Elsevier Ltd. All rights reserved.
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