期刊
NEUROCHEMICAL RESEARCH
卷 39, 期 4, 页码 707-718出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-014-1259-5
关键词
Dendropanax morbifera Leveille; Parkinson's disease; Rotenone; Rutin; SH-SY5Y cells
资金
- Leaders in INdustry-university Cooperation (LINC) Project, Ministry of Education, Republic of Korea
Dendropanax morbifera Leveille (Araliaceae) is well known in Korean traditional medicine for a variety of diseases. Rotenone is a commonly used neurotoxin to produce in vivo and in vitro Parkinson's disease models. This study was designed to elucidate the processes underlying neuroprotection of rutin, a bioflavonoid isolated from D. morbifera Leveille in cellular models of rotenone-induced toxicity. We found that rutin significantly decreased rotenone-induced generation of reactive oxygen species levels in SH-SY5Y cells. Rutin protected the increased level of intracellular Ca2+ and depleted level of mitochondrial membrane potential (Delta Im) induced by rotenone. Furthermore, it prevented the decreased ratio of Bax/Bcl-2 caused by rotenone treatment. Additionally, rutin protected SH-SY5Y cells from rotenone-induced caspase-9 and caspase-3 activation and apoptotic cell death. We also observed that rutin repressed rotenone-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase phosphorylation. These results suggest that rutin may have therapeutic potential for the treatment of neurodegenerative diseases associated with oxidative stress.
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