期刊
NEUROCHEMICAL RESEARCH
卷 39, 期 10, 页码 1942-1947出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-014-1245-y
关键词
GABA; Muscimol; GABA receptors; GABA transporters
Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(A (R))) and 4-PIOL.
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