期刊
NEUROCHEMICAL RESEARCH
卷 38, 期 6, 页码 1156-1162出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-013-0987-2
关键词
NMDAR; D-serine; Glycine; Synaptic plasticity
资金
- Wellcome Trust
- Medical Research Council UK
- Fondation pour la Recherche Medicale
- European Marie Curie Actions (EMBOCOFUND) [GA-2010-267146]
- UCL Grand Challenge Program
- UCL Excellence Fellowship
- NRW-Ruckkehrerprogramm
- Human Frontiers Science Program
- European Molecular Biology Organization
- MRC [G0802216, G0900613] Funding Source: UKRI
- Medical Research Council [G0900613, G0802216] Funding Source: researchfish
Neuronal N-methyl-d-aspartate receptors (NMDARs) play a critical role in synaptic plasticity. Their activation requires not only binding of their ligand glutamate and membrane depolarization but also the presence of a co-agonist, glycine or d-serine. An increasing body of experimental evidence suggests that different populations of NMDARs could be gated by different co-agonists. Here we discuss how the spatial distribution of co-agonist sources and uptake mechanisms, together with diffusional properties of the synaptic environment, could shape NMDAR co-agonist supply and therefore NMDAR-dependent plasticity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据