期刊
NEUROCHEMICAL RESEARCH
卷 35, 期 12, 页码 1916-1921出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-010-0257-5
关键词
Pyruvate carboxylation; Glucose; Magnetic resonance spectroscopy; Acetate; Glutamate; Glutamine
Pyruvate carboxylation is of great importance in the brain since it is responsible for adding net carbons to the tricarboxylic acid cycle following removal of carbon backbone for synthesis of the two most abundant neurotransmitters, glutamate and GABA. Despite having such a pivotal role, there is still much uncertainty in the exact metabolic details about where and how this carbon is returned. Pyruvate carboxylation has been studied in various model systems of the brain and C-13 magnetic resonance spectroscopy is an excellent tool for doing this. This review will focus on results dealing with the extent and cellular location of pyruvate carboxylation and its role in pathophysiology and concludes that pyruvate carboxylation is an extraordinarily important predominantly astrocytic pathway which plays a pivotal part in a number of diseases.
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