期刊
NEUROCHEMICAL RESEARCH
卷 36, 期 7, 页码 1166-1174出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-010-0353-6
关键词
IRBIT; IP3 receptors; NBCe1-B; CFTR; NHE3; Fip1
资金
- NIDCR NIH HHS [R01 DE012309-14, R01 DE012309] Funding Source: Medline
IRBIT (IP(3)Rs binding protein released with IP3) is a protein originally identified by the Mikoshiba group as an inhibitor of IP3 receptors function. Subsequently it was found to have multiple functions and regulate the activity of diverse proteins, including regulation of HCO3- transporters to coordinate epithelial HCO3- secretion and to determine localization of the Fip1 subunit of the CPSF complex to regulate mRNA processing. This review highlights the remarkably divers functions of IRBIT that are likely only a fraction of all the potential functions of this protein.
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