期刊
NEUROCHEMICAL RESEARCH
卷 34, 期 10, 页码 1792-1804出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-009-9985-9
关键词
Calcium/calmodulin; Molecular targeting; Cell signalling; Protein phosphorylation; CaMKII
资金
- National Health and Medical Research Council of Australia
- Hunter Medical Research Institute
CaMKII (calcium/calmodulin-stimulated protein kinase II) is a multifunctional protein kinase that regulates normal neuronal function. CaMKII is regulated by multi-site phosphorylation, which can alter enzyme activity, and targeting to cellular microdomains through interactions with binding proteins. These proteins integrate CaMKII into multiple signalling pathways, which lead to varied functional outcomes following CaMKII phosphorylation, depending on the identity and location of the binding partner. A new phosphorylation site on CaMKII (Thr253) has been identified in vivo. Thr253 phosphorylation controls CaMKII purely by targeting, does not effect enzyme activity, and occurs in response to physiological and pathological stimuli in vivo, but only in CaMKII molecules present in specific cellular locations. This new phosphorylation site offers a potentially novel regulatory mechanism for controlling functional responses elicited by CaMKII that are restricted to specific subcellular locations and/or certain cell types, by controlling interactions with proteins that are expressed in the cell at that location.
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