期刊
NEUROCHEMICAL RESEARCH
卷 33, 期 11, 页码 2288-2293出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-008-9716-7
关键词
pericyte; iron; transferrin; transferrin-binding protein (TfBP)
资金
- Brain Research Center of the 21st Century Frontier Research Program [M103KV 010018 04K2201 01850]
- Ministry of Science and Technology, the Republic of Korea
- Seoul National University Hospital Research Fund [800-2002-0111]
Transferrin-binding protein (TfBP) has been shown to be a novel protein, structurally related to the chicken heat shock protein 108. The physiological function of this protein, however, has not yet been established. Antiserum to TfBP selectively stains transferrin- and iron-rich oligodendrocytes and choroidal epithelium in the adult and embryonic chick brain, suggesting a role for this protein in transferrin and iron storage in these cells. In this study, we further demonstrate TfBP-immunoreactivity (IR) in the blood vessels of the embryonic chick central nervous system. A strong TfBP-IR was present in blood vessels from E6, declined from E10 and was absent by E18. Thus, the expression of the TfBP in the blood vessels precedes its expression in the oligodendrocytes. At the subcellular level, TfBP-IR was confined to the cytoplasm of capillary pericytes while the Tf-receptor IR was associated with the capillary endothelium of the brain. The up-regulated expression of TfBP, together with the Tf-receptor of the brain capillaries, suggests that pericytes may be associated with the high iron uptake required for the metabolic demands of the developing brain.
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