Exosome Drug Delivery through the Blood-Brain Barrier: Experimental Approaches and Potential Applications

This review discusses the current experimental data on targeted drug delivery through the blood-brain barrier (BBB). We focus on exosome drug delivery and examine the unique biological structure of exosomes, which allows them to pack, store, and deliver various molecules to the brain. Various approaches to modification and engineering of exosomes are reviewed with an analysis of experimental studies of exosome drug delivery through the BBB. The problems associated with potential clinical uses of exosomes and their possible solutions are discussed.