期刊
NEUROCHEMICAL JOURNAL
卷 8, 期 4, 页码 301-305出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1819712414040138
关键词
epilepsy; model of maximum electroshock; antagonists of AMPA receptors; glutamate receptors
资金
- Russian Foundation for Basic Research [14-04-00413, 13-04-00224, 12-04-01080, 13-04-00453]
- Presidium of the Russian Academy of Sciences [5, 7]
It is known that activation of ionotropic glutamate receptors plays a leading role in the initiation of seizures and their spreading; however, contribution of one of the subtypes of these receptors, calcium-permeable AMPA receptors (Ca-AMPAR) to seizures is practically unknown. The anticonvulsant action of two Ca-AMPAR blockers, IEM-1754 and IEM-1925, as well as the combination of IEM-1925 with the NMDA channel blocker IEM-1921, was studied in Wistar rats using the maximum electroshock model. It was shown that two Ca-AMPAR blockers are unable to prevent the development of generalized tonic seizures that were induced by electroshock. The combination of IEM-1921 and IEM-1925 did not have a stronger anticonvulsant action than IEM-1921 alone. These results reflect the weak involvement of Ca-AMPAR in the realization of tonic seizures induced by the maximum electroshock.
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