期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 116, 期 -, 页码 90-95出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2014.09.002
关键词
Transcription; Spatial memory; Fear conditioning; Object-location memory; Hippocampus
资金
- NIH [R01MH087463, S10RR027374-01A1, T32 GM008076]
- Penn Center for Musculoskeletal Disorders from the National Institute of Arthritis, Musculoskeletal and Skin Diseases [P30AR050950]
Hippocampus-dependent learning is known to induce changes in gene expression, but information on gene expression differences between different learning paradigms that require the hippocampus is limited. The bulk of studies investigating RNA expression after learning use the contextual fear conditioning task, which couples a novel environment with a footshock. Although contextual fear conditioning has been useful in discovering gene targets, gene expression after spatial memory tasks has received less attention. In this study, we used the object-location memory task and studied gene expression at two time points after learning in a high-throughput manner using a microfiuidic qPCR approach. We found that expression of the classic immediate-early genes changes after object-location training in a fashion similar to that observed after contextual fear conditioning. However, the temporal dynamics of gene expression are different between the two tasks, with object-location memory producing gene expression changes that last at least 2 hours. Our findings indicate that different training paradigms may give rise to distinct temporal dynamics of gene expression after learning. (C) 2014 Elsevier Inc. All rights reserved.
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