期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 114, 期 -, 页码 178-185出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2014.06.009
关键词
NK3 receptors; Senktide; Episodic-like memory; Object recognition
资金
- Deutsche Forschungsgemeischaft [SO1032/2-5, SO 1032/5-1]
Senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in adult and aged rodents and to facilitate episodic-like memory (ELM) in mice when administrated before the learning trial. In the present study we assessed the effects of senktide on memory consolidation by administering it post-trial (after the learning trial) in adult rats. We applied an ELM test, based on the integrated memory for object, place and temporal order, which we developed (Kart-Teke, de Souza Silva, Huston, & Dere, 2006). This test involves two learning trials and one test trial. We examined intervals of 1 h and 23 h between the learning and test trials (experiment I) in untreated animals and found that they exhibited intact ELM after a delay of I h, but not 23 h. In another test for ELM performed 7 days later, vehicle or senktide (0.2 mg/kg, s.c.) was applied immediately after the second learning trial and the test was conducted 23 h later (experiment 2). Senktide treatment recovered components of ELM (memory for place and object) compared with vehicle-treated animals. After one more week, vehicle or senktide (0.2 mg/kg, s.c.) was applied post-trial and the test conducted 6 h later (experiment 3). The senktide-treated group exhibited intact ELM, unlike the vehicle-treated group. Finally, animals received post-trial treatment with either vehicle or SR142801, a selective NK3-R antagonist (6 mg/kg, i.p.), 1 min before senktide injection (0.2 mg/kg, s.c.) in the ELM paradigm and were tested 6 h later (experiment 4). The vehicle + senktide group showed intact ELM, while the SRI 42801 + senktide group did not. The results indicate that senktide facilitated the consolidation or the expression of ELM and that the senktide effect was NIC3-R dependent. (C) 2014 Elsevier Inc. All rights reserved.
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