期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 91, 期 1, 页码 58-65出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2008.08.009
关键词
Learning; Memory; Olfaction; Mice; Proactive interference; Retroactive interference; Protein synthesis; Amnesia; Memory consolidation
Previous studies investigating the processes which underlie memory consolidation focused almost exclusively on isolated learning events. Here I studied the competition of two similar memory traces for consolidation non-conditioned recognition memory in adult male C57BL/6JOlaHsd mice using the olfactory cues based social discrimination procedure. My results show that the interference phenomena that cause forgetting are time-dependent, and that retroactive interference can be discriminated from proactive interference. Furthermore, both types of interference can be suppressed by subcutaneous anisomycin treatment immediately after presentation of the interference stimulus. These findings imply that interference phenomena, which result from the competition of two similar memory traces for long-term recognition memory, are related to the progress of memory consolidation and linked to protein synthesis. (C) 2008 Elsevier Inc. All rights reserved.
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