期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 90, 期 1, 页码 171-177出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2008.03.005
关键词
allopregnanolone; hippocampus; cortex; learning and memory; neurosteroids
资金
- NIMH NIH HHS [R01 MH067698, R01 MH067698-01A2] Funding Source: Medline
Research on how steroid hormones mediate mnemonic processes have focused on effects of 17 beta-estradiol (E-2); yet, progesterone (P-4) co-varies with E-2 across endogenous hormonal milieu, and itself may influence cognitive processes. We investigated the hypothesis that acute P-4 treatment enhances cognitive performance compared to vehicle. Ovariectomized (OVX) c57/BL6j mice were randomly assigned to be subcutaneously injected with oil vehicle or P-4 (10 mg/kg). Mice were trained in the spontaneous alternation, object recognition, object placement, water maze, or fear conditioning tasks, and injected with vehicle or P-4 before training or immediately post-training, and then were tested 1, 4, or 24 h later. The data obtained from these experiments supported our hypothesis. P-4 increased the percentage of spontaneous alterations made in a T-maze more so than did vehicle. P-4, compared to vehicle, increased the percentage of time spent exploring the novel object in the object recognition task, but did not alter performance in the object placement task. P-4, compared to vehicle, decreased latencies to reach the location in the water maze where the platform had been during training in a probe trial, but did not alter performance in the control, cued trial. Compared to vehicle, P-4 treatment increased freezing in contextual and cued fear testing. Thus, acute P-4 treatment to OVX mice can improve cognitive performance across a variety of tasks. (C) 2008 Elsevier Inc. All rights reserved.
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