期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 89, 期 2, 页码 125-133出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2007.07.002
关键词
learning; hippocampus; afterhyperpolarization; I-M; sI(AHP); neuronal excitability; calcium-activated potassium currents
资金
- NIA NIH HHS [R37 AG008796-12S1, R37 AG008796-16S2, R37 AG008796-12, R37 AG008796-16, R37 AG008796-14, R37 AG008796-09S1, R37 AG008796-11, R37 AG008796-17S1, R37 AG008796-13S1, R37 AG008796-15S1, R37 AG08796, R37 AG008796, R37 AG008796-10, R37 AG008796-13, R37 AG008796-10S1, R37 AG008796-09, R37 AG008796-17, R37 AG008796-15, R37 AG008796-16S1] Funding Source: Medline
- NIMH NIH HHS [F31 MH012761, F31 MH012761-03, F31 MH012761-01A1, F31 MH12761, F31 MH012761-02] Funding Source: Medline
Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, I-M, was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sI(AHP), was observed to underlie the learning-specific change. (C) 2007 Elsevier Inc. All rights reserved.
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