期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 90, 期 2, 页码 460-466出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2008.05.011
关键词
extinction; rat; recent memory; remote memory; Morris water maze
资金
- French Agence Nationale de la Recherche [ANR-06-NEURO-027-04]
- ULP
- CNRS
- French Ministere de l'Enseignement Superieur et de la Recherche
Extinction has mostly been studied in conditioning paradigms, more sparsely in spatial tasks, and never as a function of the age of a spatial memory. Using rats, we compared the time-course of extinction of a recent (5 days) vs. remote (25 days) spatial memory in a water maze, over three probe trials. When the trials were set 24 h apart, performance in the remote memory group was significantly worse on the first probe trial and significantly better on the third probe trial, as compared to the recent memory group, thereby showing differences between cognitive operations underlying recent vs. remote memory extinction. In contrast, when trials were given consecutively, both groups showed a similar profile of extinction. Furthermore, in a room with overly-salient cues providing a strong remote memory trace, no difference between groups was observed when the spaced extinction paradigm was used. These results might be related to a balance between reconsolidation and extinction processes occurring after a first retrieval experience, of which the outcome may depend on the extinction protocol, and on the age and strength of a memory. (C) 2008 Elsevier Inc. All rights reserved.
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